Altered brain gene expression but not steroid biochemistry in a genetic mouse model of neurodevelopmental disorder

BACKGROUND: The 39,X(Y*)O mouse, which lacks the orthologues of the ADHD and autism candidate genes STS (steroid sulphatase) and ASMT (acetylserotonin O-methyltransferase), exhibits behavioural phenotypes relevant to developmental disorders. The neurobiology underlying these phenotypes is unclear, a...

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Sonraí Bibleagrafaíochta
Main Authors: Trent, Simon, Fry, Jonathan P, Ojarikre, Obah A, Davies, William
Formáid: Artigo
Teanga:Inglês
Foilsithe: BioMed Central 2014
Ábhair:
Research
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3946266/
https://ncbi.nlm.nih.gov/pubmed/24602487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2040-2392-5-21
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