TRIP-1 via AKT modulation drives lung fibroblast/myofibroblast trans-differentiation

BACKGROUND: Myofibroblasts are the critical effector cells in the pathogenesis of pulmonary fibrosis which carries a high degree of morbidity and mortality. We have previously identified Type II TGFβ receptor interacting protein 1 (TRIP-1), through proteomic analysis, as a key regulator of collagen...

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Bibliografiska uppgifter
Huvudupphovsmän: Nyp, Michael F, Navarro, Angels, Rezaiekhaligh, Mohammad H, Perez, Ricardo E, Mabry, Sherry M, Ekekezie, Ikechukwu I
Materialtyp: Artigo
Språk:Inglês
Publicerad: BioMed Central 2014
Ämnen:
Research
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3946032/
https://ncbi.nlm.nih.gov/pubmed/24528651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1465-9921-15-19
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