Thymic abnormalities and enhanced apoptosis of thymocytes and bone marrow cells in transgenic mice overexpressing Cu/Zn-superoxide dismutase: implications for Down syndrome.

The copper-zinc superoxide dismutase (CuZnSOD) gene resides on chromosome 21 and is overexpressed in Down syndrome (DS) patients. Transgenic CuZnSOD mice with elevated levels of CuZnSOD were used to determine whether, as in DS, overexpression of CuZnSOD was also associated with thymus and bone marro...

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Detalles Bibliográficos

Publicado en:	EMBO J
Principais autores:	Peled-Kamar, M, Lotem, J, Okon, E, Sachs, L, Groner, Y
Formato:	Artigo
Idioma:	Inglês
Publicado:	Nature Publishing Group 1995
Assuntos:	Research Article
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC394602/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7588627/ https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1995.tb00181.x
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