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Motif-directed redesign of enzyme specificity
Computational protein design relies on several approximations, including the use of fixed backbones and rotamers, to reduce protein design to a computationally tractable problem. However, allowing backbone and off-rotamer flexibility leads to more accurate designs and greater conformational diversit...
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| Hauptverfasser: | , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Blackwell Publishing Ltd
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3945839/ https://ncbi.nlm.nih.gov/pubmed/24407908 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2417 |
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