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Motif-directed redesign of enzyme specificity

Computational protein design relies on several approximations, including the use of fixed backbones and rotamers, to reduce protein design to a computationally tractable problem. However, allowing backbone and off-rotamer flexibility leads to more accurate designs and greater conformational diversit...

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Podrobná bibliografie
Hlavní autoři: Borgo, Benjamin, Havranek, James J
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Publishing Ltd 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3945839/
https://ncbi.nlm.nih.gov/pubmed/24407908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2417
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