Inhibition of PKC disrupts addiction-related memory

The atypical PKC isoforms, PKMζ and PKCλ have been proposed as integral substrates of long-term memory (LTM). Inhibition of these isoforms has recently been demonstrated to be sufficient for impairing the expression and maintenance of long-term potentiation. Additionally, the pseudosubstrate inhibit...

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Hlavní autoři: Howell, Kristin K., Monk, Bradley R., Carmack, Stephanie A., Mrowczynski, Oliver D., Clark, Robert E., Anagnostaras, Stephan G.
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2014
Témata:
Neuroscience
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3945752/
https://ncbi.nlm.nih.gov/pubmed/24639635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnbeh.2014.00070
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