A SnapShot of Ubiquitin Chain Elongation: LYSINE 48-TETRA-UBIQUITIN SLOWS DOWN UBIQUITINATION

We have explored the mechanisms of polyubiquitin chain assembly with reconstituted ubiquitination of IκBα and β-catenin by the Skp1-cullin 1-βTrCP F-box protein (SCF(βTrCP)) E3 ubiquitin (Ub) ligase complex. Competition experiments revealed that SCF(βTrCP) formed a complex with IκBα and that the Ned...

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Autors principals: Kovacev, Jordan, Wu, Kenneth, Spratt, Donald E., Chong, Robert A., Lee, Chan, Nayak, Jaladhi, Shaw, Gary S., Pan, Zhen-Qiang
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2014
Matèries:
Protein Synthesis and Degradation
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3945367/
https://ncbi.nlm.nih.gov/pubmed/24464578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.530576
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