Par6 is an essential mediator of apoptotic response to transforming growth factor beta in NMuMG immortalized mammary cells

BACKGROUND: We previously observed that the TGFbeta-Par6 pathway mediates loss of polarity and apoptosis in NMuMG cells. Here we investigate the contribution of Par6 versus TGFbeta receptor I activation to TGFbeta-induced apoptosis in association with changes in apico-basal polarity. We focus on the...

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Библиографические подробности
Главные авторы: Avery-Cooper, Geordon, Doerr, Meghan, Gilbert, Richard WD, Youssef, Mahmoud, Richard, Amy, Huether, Patricia, Viloria-Petit, Alicia M
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2014
Предметы:
Primary Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3945291/
https://ncbi.nlm.nih.gov/pubmed/24581220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2867-14-19
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