PARP-1/2 Inhibitor Olaparib Prevents or Partially Reverts EMT Induced by TGF-β in NMuMG Cells

Poly- adenosine diphosphate (ADP)-ribose (PAR) is a polymer synthesized as a posttranslational modification by some poly (ADP-ribose) polymerases (PARPs), namely PARP-1, PARP-2, tankyrase-1, and tankyrase-2 (TNKS-1/2). PARP-1 is nuclear and has also been detected in extracellular vesicles. PARP-2 an...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Schacke, Michelle, Kumar, Janani, Colwell, Nicholas, Hermanson, Kole, Folle, Gustavo A., Nechaev, Sergei, Dhasarathy, Archana, Lafon-Hughes, Laura
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6387051/
https://ncbi.nlm.nih.gov/pubmed/30691122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms20030518
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