Structural Insights into E. coli Porphobilinogen Deaminase during Synthesis and Exit of 1-Hydroxymethylbilane

Porphobilinogen deaminase (PBGD) catalyzes the formation of 1-hydroxymethylbilane (HMB), a crucial intermediate in tetrapyrrole biosynthesis, through a step-wise polymerization of four molecules of porphobilinogen (PBG), using a unique dipyrromethane (DPM) cofactor. Structural and biochemical studie...

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Bibliographic Details
Main Authors: Bung, Navneet, Pradhan, Meenakshi, Srinivasan, Harini, Bulusu, Gopalakrishnan
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3945110/
https://ncbi.nlm.nih.gov/pubmed/24603363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1003484
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