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The Open Gate of the KV1.2 Channel: Quantum Calculations Show the Key Role of Hydration

The open gate of the K(v)1.2 voltage-gated potassium channel can just hold a hydrated K(+) ion. Quantum calculations starting from the x-ray coordinates of the channel confirm this, showing little change from the x-ray coordinates for the protein. Water molecules not in the x-ray coordinates, and th...

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Detalhes bibliográficos
Main Authors: Kariev, Alisher M., Njau, Philipa, Green, Michael E.
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3945100/
https://ncbi.nlm.nih.gov/pubmed/24507595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2013.11.4495
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