p-Hydroxyphenylpyruvate, an Intermediate of the Phe/Tyr Catabolism, Improves Mitochondrial Oxidative Metabolism under Stressing Conditions and Prolongs Survival in Rats Subjected to Profound Hemorrhagic Shock

The aim of this study was to test the effect of a small volume administration of p-hydroxyphenylpyruvate (pHPP) in a rat model of profound hemorrhagic shock and to assess a possible metabolic mechanism of action of the compound. The results obtained show that hemorrhaged rats treated with 2–4% of th...

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Hauptverfasser: Cotoia, Antonella, Scrima, Rosella, Gefter, Julia V., Piccoli, Claudia, Cinnella, Gilda, Dambrosio, Michele, Fink, Mitchell P., Capitanio, Nazzareno
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2014
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3944966/
https://ncbi.nlm.nih.gov/pubmed/24599095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0090917
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