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Synthesis of PPAR-γ Activators Inspired by the Marine Natural Product, Paecilocin A
A series of N-substituted phthalimide derivatives were synthesized based on a pharmacophore study of paecilocin A (a natural PPAR-γ agonist) and synthetic leads. The introduction of hydrophilic and hydrophobic groups to the phthalimide skeleton yielded compounds 3–14. Compound 7 showed significant P...
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| Hlavní autoři: | , , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
MDPI
2014
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| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3944523/ https://ncbi.nlm.nih.gov/pubmed/24531188 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md12020926 |
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