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Another Facet to the Anticancer Response to Lamellarin D: Induction of Cellular Senescence through Inhibition of Topoisomerase I and Intracellular Ros Production

Lamellarin D (LamD) is a marine alkaloid with broad spectrum antitumor activities. Multiple intracellular targets of LamD, which affect cancer cell growth and induce apoptosis, have been identified. These include nuclear topoisomerase I, relevant kinases (such as cyclin-dependent kinase 2) and the m...

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Detalhes bibliográficos
Main Authors: Ballot, Caroline, Martoriati, Alain, Jendoubi, Manel, Buche, Sébastien, Formstecher, Pierre, Mortier, Laurent, Kluza, Jérome, Marchetti, Philippe
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3944515/
https://ncbi.nlm.nih.gov/pubmed/24473175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md12020779
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