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IL-2 gene expression and NF-kappa B activation through CD28 requires reactive oxygen production by 5-lipoxygenase.

Activation of the CD28 surface receptor provides a major costimulatory signal for T cell activation resulting in enhanced production of interleukin-2 (IL-2) and cell proliferation. In primary T lymphocytes we show that CD28 ligation leads to the rapid intracellular formation of reactive oxygen inter...

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Bibliografske podrobnosti
Main Authors: Los, M, Schenk, H, Hexel, K, Baeuerle, P A, Dröge, W, Schulze-Osthoff, K
Format: Artigo
Jezik:Inglês
Izdano: 1995
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC394448/
https://ncbi.nlm.nih.gov/pubmed/7641692
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