Tetraspanin CD9 modulates ADAM17-mediated shedding of LR11 in leukocytes

LR11, also known as SorLA or SORL1, is a type-I membrane protein from which a large extracellular part, soluble LR11 (sLR11), is released by proteolytic shedding on cleavage with a disintegrin and metalloproteinase 17 (ADAM17). A shedding mechanism is presumed to have a key role in the functions of...

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Detalhes bibliográficos
Main Authors: Tsukamoto, Shokichi, Takeuchi, Masahiro, Kawaguchi, Takeharu, Togasaki, Emi, Yamazaki, Atsuko, Sugita, Yasumasa, Muto, Tomoya, Sakai, Shio, Takeda, Yusuke, Ohwada, Chikako, Sakaida, Emiko, Shimizu, Naomi, Nishii, Keigo, Jiang, Meizi, Yokote, Koutaro, Bujo, Hideaki, Nakaseko, Chiaki
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3944444/
https://ncbi.nlm.nih.gov/pubmed/24699135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emm.2013.161
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