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The Impact of Unprotected T Cells in RNAi-based Gene Therapy for HIV-AIDS

RNA interference (RNAi) is highly effective in inhibiting human immunodeficiency virus type 1 (HIV-1) replication by the expression of antiviral short hairpin RNA (shRNA) in stably transduced T-cell lines. For the development of a durable gene therapy that prevents viral escape, we proposed to combi...

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Autori principali: Herrera-Carrillo, Elena, Liu, Ying Poi, Berkhout, Ben
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3944328/
https://ncbi.nlm.nih.gov/pubmed/24336172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2013.280
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