TLR4 mediates the impairment of ubiquitin-proteasome and autophagy-lysosome pathways induced by ethanol treatment in brain

New evidence indicates the involvement of protein degradation dysfunctions in neurodegeneration, innate immunity response and alcohol hepatotoxicity. We recently demonstrated that ethanol increases brain proinflammatory mediators and causes brain damage by activating Toll-like receptor 4 (TLR4) sign...

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Bibliographische Detailangaben
Hauptverfasser: Pla, A, Pascual, M, Renau-Piqueras, J, Guerri, C
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2014
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3944260/
https://ncbi.nlm.nih.gov/pubmed/24556681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.46
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