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TLR4 mediates the impairment of ubiquitin-proteasome and autophagy-lysosome pathways induced by ethanol treatment in brain

New evidence indicates the involvement of protein degradation dysfunctions in neurodegeneration, innate immunity response and alcohol hepatotoxicity. We recently demonstrated that ethanol increases brain proinflammatory mediators and causes brain damage by activating Toll-like receptor 4 (TLR4) sign...

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Detalhes bibliográficos
Main Authors: Pla, A, Pascual, M, Renau-Piqueras, J, Guerri, C
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3944260/
https://ncbi.nlm.nih.gov/pubmed/24556681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.46
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