High-dose of vitamin C supplementation reduces amyloid plaque burden and ameliorates pathological changes in the brain of 5XFAD mice

Blood–brain barrier (BBB) breakdown and mitochondrial dysfunction have been implicated in the pathogenesis of Alzheimer's disease (AD), a neurodegenerative disease characterized by cognitive deficits and neuronal loss. Besides vitamin C being as one of the important antioxidants, recently, it h...

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Detalhes bibliográficos
Main Authors: Kook, S-Y, Lee, K-M, Kim, Y, Cha, M-Y, Kang, S, Baik, S H, Lee, H, Park, R, Mook-Jung, I
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3944243/
https://ncbi.nlm.nih.gov/pubmed/24577081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.26
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