Selective Inhibition of PI3K/Akt/mTOR Signaling Pathway Regulates Autophagy of Macrophage and Vulnerability of Atherosclerotic Plaque

Macrophage infiltration contributes to the instability of atherosclerotic plaques. In the present study, we investigated whether selective inhibition of PI3K/Akt/mTOR signaling pathway can enhance the stability of atherosclerotic plaques by activation of macrophage autophagy. In vitro study, selecti...

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Detalhes bibliográficos
Main Authors: Zhai, Chungang, Cheng, Jing, Mujahid, Haroon, Wang, Hefeng, Kong, Jing, Yin, Yue, Li, Jifu, Zhang, Yun, Ji, Xiaoping, Chen, Wenqiang
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3944201/
https://ncbi.nlm.nih.gov/pubmed/24599185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0090563
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