Phosphodiesterase 3/4 Inhibitor Zardaverine Exhibits Potent and Selective Antitumor Activity against Hepatocellular Carcinoma Both In Vitro and In Vivo Independently of Phosphodiesterase Inhibition

Hepatocellular carcinoma (HCC) is the fifth common malignancy worldwide and the third leading cause of cancer-related death. Targeted therapies for HCC are being extensively developed with the limited success of sorafinib. In the present study, we investigated the potential antitumor activity of zar...

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Hauptverfasser: Sun, Liping, Quan, Haitian, Xie, Chengying, Wang, Lei, Hu, Youhong, Lou, Liguang
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2014
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3944092/
https://ncbi.nlm.nih.gov/pubmed/24598942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0090627
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