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Phosphodiesterase 3/4 Inhibitor Zardaverine Exhibits Potent and Selective Antitumor Activity against Hepatocellular Carcinoma Both In Vitro and In Vivo Independently of Phosphodiesterase Inhibition

Hepatocellular carcinoma (HCC) is the fifth common malignancy worldwide and the third leading cause of cancer-related death. Targeted therapies for HCC are being extensively developed with the limited success of sorafinib. In the present study, we investigated the potential antitumor activity of zar...

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Bibliografiske detaljer
Main Authors: Sun, Liping, Quan, Haitian, Xie, Chengying, Wang, Lei, Hu, Youhong, Lou, Liguang
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3944092/
https://ncbi.nlm.nih.gov/pubmed/24598942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0090627
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