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Moenomycin resistance mutations in Staphylococcus aureus reduce peptidoglycan chain length and cause aberrant cell division

Staphylococcus aureus is a Gram-positive pathogen with an unusual mode of cell division in that it divides in orthogonal rather than parallel planes. Through selection using moenomycin, an antibiotic proposed to target peptidoglycan glycosyltransferases (PGTs), we have generated resistant mutants co...

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Detalhes bibliográficos
Main Authors: Rebets, Yuriy, Lupoli, Tania, Qiao, Yuan, Schirner, Kathrin, Villet, Regis, Hooper, David, Kahne, Daniel, Walker, Suzanne
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3944067/
https://ncbi.nlm.nih.gov/pubmed/24255971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb4006744
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