A novel mycobacterial Hsp70-containing fusion protein targeting mesothelin augments antitumor immunity and prolongs survival in murine models of ovarian cancer and mesothelioma

BACKGROUND: Although dendritic cell (DC) vaccines are considered to be promising treatments for advanced cancer, their production and administration is costly and labor-intensive. We developed a novel immunotherapeutic agent that links a single-chain antibody variable fragment (scFv) targeting mesot...

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Bibliografiska uppgifter
Huvudupphovsmän: Yuan, Jianping, Kashiwagi, Satoshi, Reeves, Patrick, Nezivar, Jean, Yang, Yuan, Arrifin, Nadiah Hashim, Nguyen, Mai, Jean-Mary, Gilberte, Tong, Xiaoyun, Uppal, Paramjit, Korochkina, Svetlana, Forbes, Ben, Chen, Tao, Righi, Elda, Bronson, Roderick, Chen, Huabiao, Orsulic, Sandra, Brauns, Timothy, Leblanc, Pierre, Scholler, Nathalie, Dranoff, Glenn, Gelfand, Jeffrey, Poznansky, Mark C
Materialtyp: Artigo
Språk:Inglês
Publicerad: BioMed Central 2014
Ämnen:
Research
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3943805/
https://ncbi.nlm.nih.gov/pubmed/24565018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-8722-7-15
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