CXCL12/CXCR4 blockade induces multimodal anti-tumor effects that prolong survival in an immunocompetent mouse model of ovarian cancer

The chemokine CXCL12 and its receptor CXCR4 are expressed widely in human cancers including ovarian cancer, where they are associated with disease progression at the levels of tumor cell proliferation, invasion, and angiogenesis. Here we used an immunocompetent mouse model of intraperitoneal papilla...

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Detalhes bibliográficos
Main Authors: Righi, Elda, Kashiwagi, Satoshi, Yuan, Jianping, Santosuosso, Michael, Leblanc, Pierre, Ingraham, Rachel, Forbes, Benjamin, Edelblute, Beth, Collette, Brian, Xing, Deyin, Kowalski, Magdalena, Mingari, Maria Cristina, Vianello, Fabrizio, Birrer, Michael, Orsulic, Sandra, Dranoff, Glenn, Poznansky, Mark C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3959864/
https://ncbi.nlm.nih.gov/pubmed/21742774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-3143
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