GCN20, a novel ATP binding cassette protein, and GCN1 reside in a complex that mediates activation of the eIF-2 alpha kinase GCN2 in amino acid-starved cells.

GCN2 is a protein kinase that phosphorylates the alpha-subunit of translation initiation factor 2 (eIF-2) and thereby stimulates translation of GCN4 mRNA in amino acid-starved cells. We isolated a null mutation in a previously unidentified gene, GCN20, that suppresses the growth-inhibitory effect of...

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Bibliografiske detaljer

Udgivet i:	EMBO J
Principais autores:	Vazquez de Aldana, C R, Marton, M J, Hinnebusch, A G
Format:	Artigo
Sprog:	Inglês
Udgivet:	Nature Publishing Group 1995
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC394380/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7621831/ https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1995.tb07321.x
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