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Ras recruits Raf-1 to the plasma membrane for activation by tyrosine phosphorylation.
A central feature of signal transduction downstream of both receptor and oncogenic tyrosine kinases is the Ras-dependent activation of a protein kinase cascade consisting of Raf-1, Mek (MAP kinase kinase) and ERKs (MAP kinases). To study the role of tyrosine kinase activity in the activation of Raf-...
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Hauptverfasser: | , , , |
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Format: | Artigo |
Sprache: | Inglês |
Veröffentlicht: |
1995
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Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC394375/ https://ncbi.nlm.nih.gov/pubmed/7542586 |
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