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Ras recruits Raf-1 to the plasma membrane for activation by tyrosine phosphorylation.

A central feature of signal transduction downstream of both receptor and oncogenic tyrosine kinases is the Ras-dependent activation of a protein kinase cascade consisting of Raf-1, Mek (MAP kinase kinase) and ERKs (MAP kinases). To study the role of tyrosine kinase activity in the activation of Raf-...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Marais, R, Light, Y, Paterson, H F, Marshall, C J
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1995
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC394375/
https://ncbi.nlm.nih.gov/pubmed/7542586
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