Epigenetic regulation of connective tissue growth factor by microRNA-214 delivery in exosomes from mouse or human hepatic stellate cells

Connective tissue growth factor (CCN2) drives fibrogenesis in hepatic stellate cells (HSC). Here we show that CCN2 up-regulation in fibrotic or steatotic livers, or in culture-activated or ethanol-treated primary mouse HSC is associated with a reciprocal down-regulation of microRNA-214 (miR-214). By...

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Bibliographische Detailangaben
Hauptverfasser: Chen, Li, Charrier, Alyssa, Zhou, Yu, Chen, Ruju, Yu, Bo, Agarwal, Kitty, Tsukamoto, Hidekazu, Lee, L. James, Paulaitis, Michael E, Brigstock, David R
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3943742/
https://ncbi.nlm.nih.gov/pubmed/24122827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.26768
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