Genetic variation in KLK2 and KLK3 is associated with levels of hK2 and PSA in seminal plasma and in serum in young men

BACKGROUND: Genetic variants in KLK2 and KLK3 have been associated with increased serum levels of their encoded proteins human kallikrein-related peptidase 2 (hK2) and prostate-specific antigen (PSA), and with prostate cancer in older men. Catalytic PSA, possibly activated by hK2, cleaves semenogeli...

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Main Authors: Sävblom, Charlotta, Halldén, Christer, Cronin, Angel M., Säll, Torbjörn, Savage, Caroline, Vertosick, Emily A., Klein, Robert J., Giwercman, Aleksander, Lilja, Hans
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3943614/
https://ncbi.nlm.nih.gov/pubmed/24270797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1373/clinchem.2013.211219
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