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Prostate-Specific Antigen (PSA) Is Activated by KLK2 in Prostate Cancer Ex Vivo Models and in Prostate-Targeted PSA/KLK2 Double Transgenic Mice
BACKGROUND: Prostate-specific antigen (PSA) is a serine protease secreted as a zymogen. Previously, cell-free biochemical studies have identified various kallikreins (KLK) as candidate activating proteases. In this study, KLK2-mediated activation of PSA in cell-based in vitro, xenograft, and transge...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3454520/ https://ncbi.nlm.nih.gov/pubmed/20058238 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pros.21111 |
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