Prostate-Specific Antigen (PSA) Is Activated by KLK2 in Prostate Cancer Ex Vivo Models and in Prostate-Targeted PSA/KLK2 Double Transgenic Mice

BACKGROUND: Prostate-specific antigen (PSA) is a serine protease secreted as a zymogen. Previously, cell-free biochemical studies have identified various kallikreins (KLK) as candidate activating proteases. In this study, KLK2-mediated activation of PSA in cell-based in vitro, xenograft, and transge...

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Hauptverfasser: Williams, Simon A., Xu, Yi, De Marzo, Angelo M., Isaacs, John T., Denmeade, Samuel R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3454520/
https://ncbi.nlm.nih.gov/pubmed/20058238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pros.21111
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