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Evaluation of growth hormone (GH) action in mice: discovery of GH receptor antagonists and clinical indications
The discovery of a growth hormone receptor antagonist (GHA) was initially established via expression of mutated GH genes in transgenic mice. Following this discovery, development of the compound resulted in a drug termed pegvisomant, which has been approved for use in patients with acromegaly. Pegvi...
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| 主要な著者: | , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3943600/ https://ncbi.nlm.nih.gov/pubmed/24035867 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mce.2013.09.004 |
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