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Evaluation of growth hormone (GH) action in mice: discovery of GH receptor antagonists and clinical indications

The discovery of a growth hormone receptor antagonist (GHA) was initially established via expression of mutated GH genes in transgenic mice. Following this discovery, development of the compound resulted in a drug termed pegvisomant, which has been approved for use in patients with acromegaly. Pegvi...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Kopchick, John J., List, Edward O., Kelder, Bruce, Gosney, Elahu S., Berryman, Darlene E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3943600/
https://ncbi.nlm.nih.gov/pubmed/24035867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mce.2013.09.004
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