The development of benzo- and naphtho-fused quinoline-2,4-dicarboxylic acids as vesicular glutamate transporter (VGLUT) inhibitors reveals a possible role for neuroactive steroids

Substituted quinoline-2,4-dicarboxylates (QDCs) are conformationally-restricted mimics of glutamate that were previously reported to selectively block the glutamate vesicular transporters (VGLUTs). We find that expanding the QDC scaffold to benzoquinoline dicarboxylic acids (BQDC) and naphthoquinoli...

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Autors principals: Carrigan, Christina N., Patel, Sarjubhai A., Cox, Holly D., Bolstad, Erin S., Gerdes, John M., Smith, Wesley E., Bridges, Richard J., Thompson, Charles M.
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3943356/
https://ncbi.nlm.nih.gov/pubmed/24424130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2013.12.086
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