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The structure of endothiapepsin complexed with a Phe-Tyr reduced-bond inhibitor at 1.35 Å resolution

Endothiapepsin is a typical member of the aspartic proteinase family. The catalytic mechanism of this family is attributed to two conserved catalytic aspartate residues, which coordinate the hydrolysis of a peptide bond. An oligopeptide inhibitor (IC(50) = 0.62 µM) based on a reduced-bond transition...

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Hlavní autoři: Guo, J., Cooper, J. B., Wood, S. P.
Médium: Artigo
Jazyk:Inglês
Vydáno: International Union of Crystallography 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3943106/
https://ncbi.nlm.nih.gov/pubmed/24419612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2053230X13032974
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