Adeno-Associated Viruses Serotype 2-Mediated RNA Interference Efficiently Inhibits Rabies Virus Replication In Vitro and In Vivo

To investigate the potential of adeno-associated viruses serotype 2 (AAV2)-mediated RNA interference (RNAi) as an antiviral agent against rabies, recombinant AAV2 vectors expressing siRNA targeting the nucleoprotein (N) gene of rabies virus (RABV) (rAAV-N796) were constructed and evaluated. When NA...

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Detalhes bibliográficos
Main Authors: WU, Hong-Xia, WANG, Hua-Lei, GUO, Xiao-Feng, YANG, Yu-Jiao, MA, Jin-Zhu, WANG, Tie-Cheng, GAO, Yu-Wei, ZHAO, Yong-Kun, YANG, Song-Tao, XIA, Xian-Zhu
Formato: Artigo
Idioma:Inglês
Publicado em: The Japanese Society of Veterinary Science 2013
Assuntos:
Virology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3942934/
https://ncbi.nlm.nih.gov/pubmed/23774028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1292/jvms.13-0127
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