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Synergy of ricin A chain-containing immunotoxins and ricin B chain-containing immunotoxins in in vitro killing of neoplastic human B cells.

A strategy is described for improving the efficacy of ricin A chain-containing immunotoxins. Highly purified preparations of ricin A chain or ricin B chain were separately coupled to anti-human immunoglobulin antibodies and the conjugates (immunotoxins) were affinity purified to eliminate free chain...

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Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Vitetta, E S, Cushley, W, Uhr, J W
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 1983
Sujets:
Accès en ligne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC394291/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6578512/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.80.20.6332
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