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IL-18 Expression Results in a Recombinant Vaccinia Virus That Is Highly Attenuated and Immunogenic
Interferon-γ (IFN-γ) is an attenuating factor for vaccinia virus (VACV), decreasing its virulence in vivo by more than a million fold. It is also a highly effective adjuvant when administered at the time of immunization with protein antigens. However, recombinant VACV (rVACV) vaccines expressing IFN...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Mary Ann Liebert, Inc.
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3942681/ https://ncbi.nlm.nih.gov/pubmed/24168450 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/jir.2013.0052 |
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