Vaccinia Virus Vectors with an Inactivated Gamma Interferon Receptor Homolog Gene (B8R) Are Attenuated In Vivo without a Concomitant Reduction in Immunogenicity

The vaccinia virus (VV) B8R gene encodes a secreted protein with homology to the gamma interferon (IFN-γ) receptor. In vitro, the B8R protein binds to and neutralizes the antiviral activity of several species of IFN-γ, including human and rat IFN-γ; it does not, however, bind significantly to murine...

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Bibliographic Details
Main Authors: Verardi, Paulo H., Jones, Leslie A., Aziz, Fatema H., Ahmad, Shabbir, Yilma, Tilahun D.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2001
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC113892/
https://ncbi.nlm.nih.gov/pubmed/11119568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.75.1.11-18.2001
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