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SCH 79797, a selective PAR1 antagonist, limits myocardial ischemia/reperfusion injury in rat hearts
Myocardial ischemia/reperfusion (I/R) injury is partly mediated by thrombin. In support, the functional inhibition of thrombin has been shown to decrease infarct size after I/R. Several cellular responses to thrombin are mediated by a G-protein coupled protease-activated receptor 1 (PAR1). However,...
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| Auteurs principaux: | , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2007
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3942648/ https://ncbi.nlm.nih.gov/pubmed/17468933 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00395-007-0653-4 |
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