Cocaine Disrupts Histamine H(3) Receptor Modulation of Dopamine D(1) Receptor Signaling: σ(1)-D(1)-H(3) Receptor Complexes as Key Targets for Reducing Cocaine's Effects

The general effects of cocaine are not well understood at the molecular level. What is known is that the dopamine D(1) receptor plays an important role. Here we show that a key mechanism may be cocaine's blockade of the histamine H(3) receptor-mediated inhibition of D(1) receptor function. This...

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Main Authors: Moreno, Estefanía, Moreno-Delgado, David, Navarro, Gemma, Hoffmann, Hanne M., Fuentes, Silvia, Rosell-Vilar, Santi, Gasperini, Paola, Rodríguez-Ruiz, Mar, Medrano, Mireia, Mallol, Josefa, Cortés, Antoni, Casadó, Vicent, Lluís, Carme, Ferré, Sergi, Ortiz, Jordi, Canela, Enric, McCormick, Peter J.
Format: Artigo
Jezik:Inglês
Izdano: Society for Neuroscience 2014
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Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3942573/
https://ncbi.nlm.nih.gov/pubmed/24599455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4147-13.2014
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