Alpha-Lipoic Acid Reduces LDL-Particle Number and PCSK9 Concentrations in High-Fat Fed Obese Zucker Rats

We characterized the hypolipidemic effects of alpha-lipoic acid (LA, R-form) and examined the associated molecular mechanisms in a high fat fed Zucker rat model. Rats (n = 8) were assigned to a high fat (HF) diet or the HF diet with 0.25% LA (HF-LA) for 30 days and pair fed to remove confounding eff...

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Main Authors: Carrier, Bradley, Wen, Shin, Zigouras, Sophia, Browne, Richard W., Li, Zhuyun, Patel, Mulchand S., Williamson, David L., Rideout, Todd C.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2014
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3942488/
https://ncbi.nlm.nih.gov/pubmed/24595397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0090863
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