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Proteolytic E-cadherin activation followed by solution NMR and X-ray crystallography

Cellular adhesion by classical cadherins depends critically on the exact proteolytic removal of their N-terminal prosequences. In this combined solution NMR and X-ray crystallographic study, the consequences of propeptide cleavage of an epithelial cadherin construct (domains 1 and 2) were followed a...

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Autors principals: Häussinger, Daniel, Ahrens, Thomas, Aberle, Thomas, Engel, Jürgen, Stetefeld, Jörg, Grzesiek, Stephan
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2004
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC394246/
https://ncbi.nlm.nih.gov/pubmed/15071499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600192
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