Protective Effect of Glycyrrhizin, a Direct HMGB1 Inhibitor, on Focal Cerebral Ischemia/Reperfusion-Induced Inflammation, Oxidative Stress, and Apoptosis in Rats

AIM: Glycyrrhizin (GL) has been reported to protect against ischemia and reperfusion (I/R)-induced injury by inhibiting the cytokine activity of high mobility group box 1 (HMGB1). In the present study, the protective effects of GL against I/R injury, as well as the related molecular mechanisms, were...

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Autori principali: Gong, Gu, Xiang, Lei, Yuan, Libang, Hu, Ling, Wu, Wei, Cai, Lin, Yin, Liang, Dong, Hailong
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3942385/
https://ncbi.nlm.nih.gov/pubmed/24594628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0089450
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