Mevinolin and colestipol stimulate receptor-mediated clearance of low density lipoprotein from plasma in familial hypercholesterolemia heterozygotes.

In subject with heterozygous familial hypercholesterolemia (FH), a 50% deficiency of receptors for plasma low density lipoprotein (LDL) impairs the removal of LDL from plasma and produces hypercholesterolemia. In these patients mevinolin, an inhibitor of 3-hydroxy-3-methylglutaryl-CoA reductase, blo...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Bilheimer, D W, Grundy, S M, Brown, M S, Goldstein, J L
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1983
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC394213/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6575399/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.80.13.4124
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