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Aphidicolin inhibits the synthesis and joining of short DNA fragments but not the union of 10-kilobase DNA replication intermediates.

DNA replication intermediates in human melanoma cells have been investigated by using the drug aphidicolin, which inhibits DNA polymerase alpha. In untreated cells, Okazaki fragments and 10-kilobase (kb) DNA intermediates are formed. In aphidicolin-treated cells, the replication fork is stopped and...

詳細記述

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書誌詳細
出版年:Proc Natl Acad Sci U S A
主要な著者: Lönn, U, Lönn, S
フォーマット: Artigo
言語:Inglês
出版事項: National Academy of Sciences 1983
主題:
オンライン・アクセス:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC394186/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6408640/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.80.13.3996
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