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Phencyclidine in nanomolar concentrations binds to synaptosomes and blocks certain potassium channels.

Phencyclidine [1-(phenylcyclohexyl)piperidine; PCP], in low dose (approximately equal to 0.1-0.2 mg/kg of body weight), induces a schizophrenia-like behavioral syndrome in man; this effect has been attributed to block of neuronal K channels. We used a K-stimulated 86Rb efflux assay to demonstrate th...

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Autors principals: Blaustein, M P, Ickowicz, R K
Format: Artigo
Idioma:Inglês
Publicat: 1983
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC394151/
https://ncbi.nlm.nih.gov/pubmed/6304743
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