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Regulation of Receptor Tyrosine Kinase Ligand Processing

A primary mode of regulating receptor tyrosine kinase (RTK) signaling is to control access of ligand to its receptor. Many RTK ligands are synthesized as transmembrane proteins. Frequently, the active ligand must be released from the membrane by proteolysis before signaling can occur. Here, we discu...

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Detalles Bibliográficos
Autores principales: Adrain, Colin, Freeman, Matthew
Formato: Artigo
Lenguaje:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2014
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3941217/
https://ncbi.nlm.nih.gov/pubmed/24384567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a008995
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