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Rapid spontaneous dihydrofolate reductase gene amplification shown by fluorescence-activated cell sorting.

We have determined whether the gene encoding dihydrofolate reductase (5,6,7,8-tetrahydrofolate: NADP+ oxidoreductase, EC 1.5.1.3) varies spontaneously in gene copy number in cells in vitro. Cells were stained under nonselective conditions with fluoresceinated methotrexate, which binds quantitatively...

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Dettagli Bibliografici
Autori principali: Johnston, R N, Beverley, S M, Schimke, R T
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1983
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC394120/
https://ncbi.nlm.nih.gov/pubmed/6574509
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