Mitochondrial DNA depletion sensitizes cancer cells to PARP inhibitors by translational and post-translational repression of BRCA2

Previous studies have shown that pharmacologic inhibition of poly (ADP-ribose) polymerase (PARP), a nuclear protein that is crucial in signaling single-strand DNA breaks, is synthetically lethal to cancer cells from patients with genetic deficiency in the DNA repair proteins BRCA1 and BRCA2. Herein,...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Arbini, A A, Guerra, F, Greco, M, Marra, E, Gandee, L, Xiao, G, Lotan, Y, Gasparre, G, Hsieh, J-T, Moro, L
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2013
Assuntos:
Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3940862/
https://ncbi.nlm.nih.gov/pubmed/24336406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/oncsis.2013.45
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares