Pentosan Polysulfate Decreases Myocardial Expression of the Extracellular Matrix Enzyme ADAMTS4 and Improves Cardiac Function In Vivo in Rats Subjected to Pressure Overload by Aortic Banding

BACKGROUND: We hypothesized that cleavage of the extracellular matrix (ECM) proteoglycans versican and aggrecan by ADAMTS (a disintegrin and metalloprotease with thrombospondin motifs) proteases, which contributes to stress-induced ECM-reorganization in atherogenesis and osteoarthritis, also play a...

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Detalhes bibliográficos
Main Authors: Vistnes, Maria, Aronsen, Jan Magnus, Lunde, Ida G., Sjaastad, Ivar, Carlson, Cathrine R., Christensen, Geir
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3940660/
https://ncbi.nlm.nih.gov/pubmed/24595230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0089621
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