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Mismatch repair gene MSH3 polymorphism is associated with the risk of sporadic prostate cancer

PURPOSE: The mismatch repair (MMR) system is a DNA repair mechanism that corrects mispaired bases during DNA replication errors. Cancer cells deficient in the MMR proteins have a 10(2) –10(3)-fold increase in the mutation rate. Single nucleotide polymorphisms (SNPs) of MMR genes have been shown to c...

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Detalhes bibliográficos
Main Authors: Hirata, Hiroshi, Hinoda, Yuji, Kawamoto, Ken, Kikuno, Nobuyuki, Suehiro, Yutaka, Okayama, Naoko, Tanaka, Yuichiro, Dahiya, Rajvir
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3940351/
https://ncbi.nlm.nih.gov/pubmed/18355840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.juro.2008.01.009
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