Mechanistic evaluation of the transfection barriers involved in lipid-mediated gene delivery: Interplay between nanostructure and composition

Here we present a quantitative mechanism-based investigation aimed at comparing the cell uptake, intracellular trafficking, endosomal escape and final fate of lipoplexes and lipid–protamine/deoxyribonucleic acid (DNA) (LPD) nanoparticles (NPs) in living Chinese hamster ovary (CHO) cells. As a model,...

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Autors principals: Pozzi, D., Marchini, C., Cardarelli, F., Salomone, F., Coppola, S., Montani, M., Zabaleta, M. Elexpuru, Digman, M.A., Gratton, E., Colapicchioni, V., Caracciolo, G.
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3940149/
https://ncbi.nlm.nih.gov/pubmed/24296066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamem.2013.11.014
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